We study how DNA repair pathways are regulated to maintain genomic integrity

 

Our

RESEARCH

Damage response

cell cycle regulation

Repair pathway

choice

DNA

DAMAGE

Repair pathway

regulation

Efficient repair of DNA damage is essential for cellular survival. When cells face DNA damage from internal or external factors, multiple steps must be taken to ensure effective repair of damage as well as restoration of wild type growth.

 

Our lab is broadly interested in studying the regulation of DNA damage response and repair pathways in vivo.

 

At present, we are addressing the following questions in microbial systems:

      a. Regulation of DNA damage response and repair clearance in bacteria

              How do cells recover after DNA damage onslaught

      b. Regulation of pathway choice during repair

             Regulation and specificity of error-prone DNA polymerases

      c. Molecular mechanism of double-strand break repair via homologous recombination

             How do double-strand break ends find their homologous partner

      d. Mitochondrial DNA repair mechanisms

             How do cells regulate mitochondrial DNA damage response and repair

We use a combination of live-cell imaging, super-resolution microscopy, high-throughput sequencing techniques as well as genetic and molecular biology assays to mechanistically understand how cells from all domains of life maintain genome integrity.

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The LAB

The LAB

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Anjana
Badrinarayanan

Principal Investigator

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Aditya Kamat
Graduate Student

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Afroze Chimthanawala
Graduate Student

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Asha Mary Joseph
Post-Doc

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Nitish Dua
Graduate Student

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Suchitha Raghunathan
Project Associate

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Saheli Daw
Graduate Student

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Akshaya Seshadri
Graduate Student

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Neha Sontakke
Research Specialist

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Sourav
Bhattacharyya
Graduate Student

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Inchara Adhikashreni
Project Assistant

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Kaustav Mitra
Graduate Student

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Srinidhi Rengarajan
Project Assistant

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Selena Moirangthem
Project Associate

 

PUBLICATIONS

 

 

OPPORTUNITIES

Thank you for your interest in joining our lab! The questions we ask are inter-disciplinary in nature and we are happy to have researchers from diverse backgrounds of science working together. Do get in touch if you are interested in questions pertaining to the maintenance of genome integrity in cells.


 

If you are writing to me (anjana[at]ncbs[dot]res[dot]in), include a copy of your CV and a brief description of research interests (related to the work done in our lab). 

At present, we do not have openings for short-term internships or MSc. thesis projects. 

 

CONTACT

ANJANA BADRINARAYANAN

NATIONAL CENTRE for BIOLOGICAL SCIENCES

GKVK Campus, Bellary Road,

Bengaluru, Karnataka 560065

Phone - 080-23666001

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