DNA damage induced bacterial filaments recover via asymmetric chromosome segregation and cell division
DNA damage induced bacterial filaments recover via asymmetric chromosome segregation and cell division

ISMATH
SADHIR
(JRF)
I work on understanding the regulation of error-prone DNA polymerases in bacteria

We study how DNA repair pathways are regulated to maintain genomic integrity
Our
RESEARCH
Damage response
cell cycle regulation
Repair pathway
choice
DNA
DAMAGE
Repair pathway
regulation
Efficient repair of DNA damage is essential for cellular survival. When cells face DNA damage from internal or external factors, multiple steps must be taken to ensure effective repair of damage as well as restoration of wild type growth.
Our lab is broadly interested in studying the regulation of DNA damage response and repair pathways in vivo.
At present, we are addressing the following questions in microbial systems:
a. Regulation of DNA damage response and repair clearance in bacteria
How do cells recover after DNA damage onslaught
b. Regulation of pathway choice during repair
Regulation and specificity of error-prone DNA polymerases
c. Molecular mechanism of double-strand break repair via homologous recombination
How do double-strand break ends find their homologous partner
d. Mitochondrial DNA repair mechanisms
How do cells regulate mitochondrial DNA damage response and repair
We use a combination of live-cell imaging, super-resolution microscopy, high-throughput sequencing techniques as well as genetic and molecular biology assays to mechanistically understand how cells from all domains of life maintain genome integrity.
The LAB
The LAB


Anjana
Badrinarayanan
Principal Investigator


Aditya Kamat
Graduate Student


Afroze Chimthanawala
Graduate Student


Asha Mary Joseph
Post-Doc


Nitish Dua
Graduate Student


Suchitha Raghunathan
Project Associate


Saheli Daw
Graduate Student


Akshaya Seshadri
Graduate Student


Neha Sontakke
Research Specialist


Sourav
Bhattacharyya
Graduate Student


Inchara Adhikashreni
Project Assistant


Kaustav Mitra
Graduate Student


Srinidhi Rengarajan
Project Assistant


Selena Moirangthem
Project Associate
PUBLICATIONS
- Adam SB Jalal, Ngat T Tran, Clare EM Stevenson, Afroze Chimthanawala, Anjana Badrinarayanan, David M Lawson, Tung BK Le*. (2021). A CTP-dependent gating mechanism enables ParB spreading on DNA. eLife. 10:e69676.
- Joseph A, Daw S, Sadhir I and Badrinarayanan A*. (2021). Coordination between nucleotide excision repair and specialized polymerase DnaE2 action enables survival in non-replicating bacteria. eLife. 10:e67552.
OPPORTUNITIES
Thank you for your interest in joining our lab! The questions we ask are inter-disciplinary in nature and we are happy to have researchers from diverse backgrounds of science working together. Do get in touch if you are interested in questions pertaining to the maintenance of genome integrity in cells.
If you are writing to me (anjana[at]ncbs[dot]res[dot]in), include a copy of your CV and a brief description of research interests (related to the work done in our lab).
At present, we do not have openings for short-term internships or MSc. thesis projects.
CONTACT
ANJANA BADRINARAYANAN
NATIONAL CENTRE for BIOLOGICAL SCIENCES
GKVK Campus, Bellary Road,
Bengaluru, Karnataka 560065
Phone - 080-23666001





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